Will was a guest on Conan, America's answer to Jonathan Ross, when he was asked about his thoughts on the scandal.
Bursting into tears, the Anchorman actor vented his distress over the break up.
He screamed: "I don' know what this means for the Twilight series. It's not going to be fine.. ever! It will never be fine! What they had was so special you don't even know!"
We didn't see that coming!
Watch the video here
Continuing his melodramatic rant, Will then exclaimed: "She is a trampire, that's what she is!"
We know we shouldn't laugh. But trampire? That's genius.
Somehow we don't see Kristen seeing the funny side of Will's joke.
[Related Story: Kristen Stewart, the most hated woman in Hollywood?]
[Related Story: Kristen Stewart banned from Robert Pattinson's Cosmopolis premiere]
Will's faux upset comes in the wake of more intimate pictures being released of the Twilight actress with Director Rupert Sanders.
It was reported yesterday that Robert Pattinson, who has since moved out of the couples shared house, had banned her from future premieres of his film Cosmopolis.
Pattinson is said to still be distraught over Stewarts betrayal, leaving Twilight fans wondering if the two will be able to put their difference aside by the time the final Twilight film is released in Novemeber.
We wonder if Will Ferrell will be invited to the premiere. He seems to be a big fan.